5-lipoxygenase(5-LOX) is a member of the lipoxygenase family of enzymes. It transforms fatty acids into leukotrienes.Excesslevels of the enzyme5-LOXsets in motion inflammatory responses that have been linked to common effects in aging individuals.70-74
Normalaging results in higher-than-desired levels of 5-LOX.
The typical American diet adds to the danger. Foods rich inomega-6 fatty acidslike red meat, poultry, eggs and dairy products, along with high-glycemic carbohydrates, trigger overproduction ofarachidonic acid. In response to high levels ofarachidonic acid, the body produces the5-LOXenzyme.
5-LOXbreaks downarachidonic acidto pro-inflammatory compounds like leukotrieneB4,75a molecule that mediates attacks to joints, arterial walls, and other tissues.5-LOXitself facilitates undesirable cell division changes.76,77
The good news is that an extract of the Indian plantBoswellia serratahas been shown to neutralize 5-LOX. Used for centuries to help with inflammatory issues, boswellia acts as a natural5-LOX inhibitor, intervening at the cellular level to block its unwanted effects. Confirmatory data reveal that a compound contained in boswellia calledAKBA(3-O-acetyl-11-keto-